Herbal medicine pdf free download






















Juliet and her houseplants share a home with her family and herb books in Asheville, North Carolina. She transplanted to the mountains of Western North Carolina in to study the vast biodiversity the Southern Appalachian region has to offer. During this time she has worked on numerous herb farms, organized and hosted herbal events, and created an herbal product line called Apothefaerie.

Excerpts and links may be used, provided that full and clear credit is given to Chestnut School of Herbal Medicine and chestnutherbs. The course begins with the basic ground rules of foraging safety and ethics, and then moves on to botany and plant identification.

The printable manual is hundreds of pages long and filled with close-up photos for identification, medicinal uses, and loads of easy-to-follow recipes. Wanted to inquire about herbalist and how I might become one to better myself, family and friends.

What a beautiful goal, Fetoren! I would suggest checking out the free Budding Herbalists Guide that we offer 16 in this post for a more extensive list of resources for herbal learning.

I am about to make a large order from Mountain Rose Herbs and they are telling me there is a discount code that qualifies me for 20 percent off, but I cant find it. Can you either email it to me or direct me to the page, please? This is a blog article, but you can find the discount code for current students in the Course Guidelines page of your course. Podcasts are also free. Real Herbalism Radio is dedicated to factual information on herbs and homesteading.

Your email address will not be published. You may use these HTML tags and attributes:. Save my name, email, and website in this browser for the next time I comment. Notify me when new comments are added. Meet Our Contributors:. Interested in becoming a contributor? Gain confidence with our Online Foraging Course!

Registration is now open! Pursue Your Dreams! Get pages of herbal resources with our Budding Herbalist Guide! Fetoren Jones says: January 7, at pm. Sarah Sorci says: January 8, at pm. Shannon Woodward says: March 31, at pm. Lisa Jacks says: November 2, at pm. Sara Kinney says: November 2, at pm. Hi Lisa, This is a blog article, but you can find the discount code for current students in the Course Guidelines page of your course.

Sue Sierralupe says: March 25, at pm. Leave a Reply Cancel Reply Your email address will not be published. You may have trouble concentrating or performing mechanical skills. Small amounts of alcohol can make it dangerous to drive, and when you mix alcohol with certain medicines you put yourself at even greater risk. Combining alcohol with some medicines can lead to falls and serious injuries, especially among older people. Some medications—including many popular painkillers and cough, cold, and allergy remedies—contain more than one ingredient that can react with alcohol.

Read the label on the medication bottle to find out exactly what ingredients a medicine contains. Ask your pharmacist if you have any questions about how alcohol might interact with a drug you are taking. Certain medicines contain up to 10 percent alcohol. Cough syrup and laxatives may have some of the highest alcohol concentrations. Women, in general, have a higher risk for problems than men. As a result, women are more susceptible to alcohol-related damage to organs such as the liver.

Older people are at particularly high risk for harmful alcohol—medication interactions. Older people also are more likely to take a medication that interacts with alcohol—in fact, they often need to take more than one of these medications. Mixing alcohol and medicines puts you at risk for dangerous reactions. To learn more about a medicine and whether it will interact with alcohol, talk to your pharmacist or other health care provider. Drowsiness, dizziness; increased risk for overdose; slowed or difficulty breathing; impaired motor control; unusual behavior; memory problems.

Dizziness, drowsiness, impaired concentration methylphenidate, dexmethylphenidate ; possible increased risk for heart problems amphetamine, dextroamphetamine, lisdexamfetamine ; liver damage atomoxetine. Although CEP has not yet been translated into clinical use for the treatment of cancer, the pharmacological activities and pre-clinical data support its significant clinical potential for anti-cancer therapy.

Chinese herbal medicine has played, and still plays, an important role in human health care in China and other Asian countries. Chinese herbal medicine is also recognized worldwide as a rich source for the discovery of novel drugs in the past decades. Table 1 illustrates the experimental models and conditions, pharmacological effects, as well as mechanistic actions of the natural compounds derived from Chinese herbal medicine.

Despite the unique anti-cancer beneficial features of many compounds derived from Chinese herbal medicine, their clinical applications are disproportionally limited. As of , only preliminary clinical studies have been performed with artemisinins, emodin, cucurbitacins, tanshiones, shikonin, and CEP in various cancers, without any approved clinical applications. The phase I safety studies of UA-liposomes, oridonin derivative HAO , and wogonin were evaluated in patients with advanced solid tumors.

The phase II clinical trials of berberine hydrochloride, ginsenoside Rg3, and artesunate are being conducted in patients with cancer. Based on our critical review of those clinical studies, we conclude that Chinese herbal medicine is a promising source and could be used as a complementary approach for cancer therapy.

We believe that as the evidence for safety and efficacy continues to develop, this will improve the understanding about the mechanistic actions and clinical potential of these compounds. Chinese herbal medicine will also serve as a huge community from which many promising compounds will be developed for clinical use. CA Cancer J Clin. Article Google Scholar.

Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy. J Ethnopharmacol. PubMed Article Google Scholar. Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells.

Chin Med. Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations. Br J Pharmacol. Curcuminoids induce reactive oxygen species and autophagy to enhance apoptosis in human oral cancer cells.

Am J Chin Med. Berberine and Coptidis Rhizoma as potential anticancer agents: recent updates and future perspectives. Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation. Physical and chemical stability of curcumin in aqueous solutions and emulsions: impact of pH, temperature, and molecular environment. J Agric Food Chem. The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.

J Exp Clin Cancer Res. Inhibition of curcumin on myeloid-derived suppressor cells is requisite for controlling lung cancer.

Int Immunopharmacol. Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomed Pharmacother. Combined effects of curcumin and triptolide on an ovarian cancer cell line. Asian Pac J Cancer Prev. J Drug Target. A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer. Sci Rep. Acs Comb Sci. Curcumin suppresses proliferation and migration of MDA-MB breast cancer cells through autophagy-dependent Akt degradation.

Characterization and anti-proliferative activity of curcumin loaded chitosan nanoparticles in cervical cancer.

Int J Biol Macromol. Curcumin analog CH-5 suppresses the proliferation, migration, and invasion of the human gastric cancer cell line HGC Molecules Basel, Switzerland. EGFR inhibition by curcumin in cancer cells: a dual mode of action. Enhancement in in vitro anti-angiogenesis activity and cytotoxicity in lung cancer cell by pectin-PVP based curcumin particulates. Curcumin inhibited growth of human melanoma A cells via inciting oxidative stress. Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death.

Curcumin induces autophagy via inhibition of yes-associated protein YAP in human colon cancer cells. Med Sci Monit. Digest Liver Dis. Oncol Rep.

Oncol Lett. Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway. J Nutr Biochem. Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis. Cancer Prevent Res Philadelphia, Pa. Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT.

Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice. Cancer Chemother Pharmacol. Eur J Med Chem. Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase gamma depletion disrupting cellular bioenergetics. Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth. Pharm Biol. Int J Clin Exp Med. Effects of curcumin on the role of MMP-2 in endometrial cancer cell proliferation and invasion.

Eur Rev Med Pharmacol Sci. PubMed Google Scholar. Biomed Res Int. Curcumin enhances the radiosensitivity of renal cancer cells by suppressing NF-kappaB signaling pathway. J Cancer Res Clin Oncol. Antiproliferative and apoptotic effect of dendrosomal curcumin nanoformulation in P53 mutant and wide-type cancer cell lines.

Anticancer Agents Med Chem. Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling. J Cell Physiol. Reduction of the clonogenic potential and collapse of the mitochondrial membrane potential in A epidermoid carcinoma cell line induced by curcumin. Rom Biotechnol Lett. CAS Google Scholar. Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A Nano-curcumin inhibits proliferation of esophageal adenocarcinoma cells and enhances the T cell mediated immune response.

Front Oncol. Transglutaminase 2 regulates self-renewal and stem cell marker of human colorectal cancer stem cells. Anticancer Res. Low-dose curcumin leads to the inhibition of tumor growth via enhancing CTL-mediated antitumor immunity.

Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma. Arch Oral Biol. Curr Drug Deliv. Hybrid nanocomposite curcumin-capped gold nanoparticle-reduced graphene oxide: anti-oxidant potency and selective cancer cytotoxicity. Redox Biol. Nano packaged tamoxifen and curcumin; effective formulation against sensitive and resistant MCF-7 cells.

Iran J Pharm Res. J Biomed Nanotechnol. Nanoparticle assisted solvent selective transdermal combination therapy of curcumin and 5-flurouracil for efficient cancer treatment. Carbohyd Polym. Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin. Combined delivery and anti-cancer activity of paclitaxel and curcumin using polymeric micelles. Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miRa.

Mol Cell Biochem. A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma. Biochem Biophys Res Commun. Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway. Synergistic anti-tumor effect of KLF4 and curcumin in human gastric carcinoma cell line.

Asian Pac J Cancer Prevent. Int J Pharm. Curcumin enhanced adriamycin-induced human liver-derived Hepatoma G2 cell death through activation of mitochondria-mediated apoptosis and autophagy.

Eur J Pharm Sci. Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. BMC Cancer. Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells. Int J Clin Oncol. The effects of curcumin diferuloylmethane on body composition of patients with advanced pancreatic cancer. A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin Lipocurc in patients with locally advanced or metastatic cancer.

A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin Theracurmin in cancer patients. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase II study. Green tea consumption and risk of cardiovascular and ischemic related diseases: a meta-analysis.

Int J Cardiol. Green tea extracts for the prevention of metachronous colorectal polyps among patients who underwent endoscopic removal of colorectal adenomas: a randomized clinical trial.

Clin Nutr Edinburgh, Scotland. Rsc Adv. Antibacterial activity of epigallocatechingallate EGCG and its synergism with beta-lactam antibiotics sensitizing carbapenem-associated multidrug resistant clinical isolates of Acinetobacter baumannii.

The anti-hyperuricemic effect of epigallocatechingallate EGCG on hyperuricemic mice. Anti-infective properties of epigallocatechingallate EGCG , a component of green tea. Epigallocatechingallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells.

OncoTargets Ther. Google Scholar. Early transcriptional pattern of angiogenesis induced by EGCG treatment in cervical tumour cells. J Cell Mol Med. Genomics Data. Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells. Leuk Lymphoma. Int J Food Sci Nutr. Formulation and characterization of EGCG for the treatment of superficial bladder cancer.

Int J Mol Med. Differences in the effects of EGCG on chromosomal stability and cell growth between normal and colon cancer cells.

Differential proteomic analysis reveals that EGCG inhibits HDGF and activates apoptosis to increase the sensitivity of non-small cells lung cancer to chemotherapy.

Proteomics Clin Appl. EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy. Cancer Cell Int. Epigallocatechingallate suppresses human herpesvirus 8 replication and induces ROS leading to apoptosis and autophagy in primary effusion lymphoma cells. Int J Mol Sci. Biosci Biotechnol Biochem. Med Oncol Northwood, London, England. Int J Oncol. Cell Death Discov. Jwa M, Chang P. Nat Cell Biol. Green tea catechin is an alternative immune checkpoint inhibitor that inhibits PD-L1 expression and lung tumor growth.

A prodrug of green tea polyphenol - -epigallocatechingallate Pro-EGCG serves as a novel angiogenesis inhibitor in endometrial cancer. Cancer Lett. Protective effects of epigallocatechin gallate EGCG derivatives on azoxymethane-induced colonic carcinogenesis in mice.

J Funct Foods. Zhong Y, Shahidi F. Lipophilized epigallocatechin gal late EGCG derivatives as novel antioxidants. Epigallocatechin gallate-beta-lactoglobulin nanoparticles improve the antitumor activity of EGCG for inducing cancer cell apoptosis. Encapsulation of biophenolic phytochemical EGCG within lipid nanoparticles enhances its stability and cytotoxicity against cancer.

Chem Phys Lipids. Preparation, characterization, and in vitro antitumor activity of folate conjugated chitosan coated EGCG nanoparticles. Food Sci Biotechnol. Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model.

Protonation of epigallocatechingallate EGCG results in massive aggregation and reduced oral bioavailability of EGCG-dispersed selenium nanoparticles. Development of - -epigallocatechingallate EGCG -loaded enteric microparticles with intestinal mucoadhesive property. Ferritin glycosylated by chitosan as a novel EGCG nano-carrier: structure, stability, and absorption analysis.

EGCG enhances cisplatin sensitivity by regulating expression of the copper and cisplatin influx transporter CTR1 in ovary cancer. Combination of low concentration of - -epigallocatechin gallate EGCG and curcumin strongly suppresses the growth of non-small cell lung cancer in vitro and in vivo through causing cell cycle arrest.

EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of P-glycoprotein inhibition. J Neurooncol. EGCG synergizes the therapeutic effect of cisplatin and oxaliplatin through autophagic pathway in human colorectal cancer cells. J Pharmacol Sci. Eur J Cancer. Br J Haematol. Combination of erlotinib and EGCG induces apoptosis of head and neck cancers through posttranscriptional regulation of Bim and Bcl Phase I study of topical epigallocatechingallate EGCG in patients with breast cancer receiving adjuvant radiotherapy.

Br J Radiol. Radiother Oncol. The metabolism of berberine and its contribution to the pharmacological effects. Drug Metab Rev. The preconditioning of berberine suppresses hydrogen peroxide-induced premature senescence via regulation of sirtuin 1.

Oxid Med Cell Longevity. Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines. Berberine induces apoptosis in pnull leukemia cells by down-regulating XIAP at the post-transcriptional level. Cell Physiol Biochem.

Berberine-induced growth inhibition of epithelial ovarian carcinoma cell lines. J Obstetr Gynaecol Res. Genomic screening for targets regulated by berberine in breast cancer cells. Integrative analysis of differential miRNA and functional study of miR by seed-targeting inhibition in multiple myeloma cells in response to berberine. BMC Syst Biol. Berberine sensitizes nasopharyngeal carcinoma cells to radiation through inhibition of Sp1 and EMT. Berberine displays antitumor activity in esophageal cancer cells in vitro.

World J Gastroenterol. Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial—mesenchymal transition in neuroblastoma cells. Berberine inhibited the growth of thyroid cancer cell lines C and TPC1. Yonsei Med J. Up-regulation of PAI-1 and down-regulation of uPA are involved in suppression of invasiveness and motility of hepatocellular carcinoma cells by a natural compound berberine. Mutat Res. Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells.

Free Radical Biol Med. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.

Berberine induces mitochondrialmediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCIH cells. Berberine reverses epithelial-to-mesenchymal transition and inhibits metastasis and tumor-induced angiogenesis in human cervical cancer cells. Mol Pharmacol. Molecular spectroscopy evidence of berberine binding to DNA: comparative binding and thermodynamic profile of intercalation. Different mechanisms involved in the berberine-induced antiproliferation effects in triple-negative breast cancer cell lines.

J Cell Biochem. The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. Eur J Pharmacol. Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway.

Tumour Biol. Braz J Med Biol Res. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. Takeda K, Akira S. Toll-like receptors. Curr Protoc Immunol. Berberine reduces Toll-like receptor-mediated macrophage migration by suppression of Src enhancement. Targeting the IDO1 pathway in cancer: from bench to bedside. J Hematol Oncol.

Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1. Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats. A new isoquinoline alkaloid with anti-microbial properties from Berberis jaeschkeana Schneid. Nat Prod Res. Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride.

Drug Dev Ind Pharm. A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.



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